Drug Standards
Apexbio Technology LLC Atazanavir 198904-31-3 10mg
Atazanavir (CAS 198904-31-3) is a small-molecule inhibitor targeting HIV-1 protease It is designed to block protease-mediated cleavage of viral gag and gag-pol polyproteins thereby preventing the maturation of infectious viral particles Atazanavir exerts its biological activity primarily through direct binding to the active site of HIV-1 protease inhibiting polyprotein cleavage In in vitro studies atazanavir demonstrates inhibition of HIV-1 replication with reported EC50 values ranging from 2 6 to 5 3 nmol/L and a protease-inhibition constant (Ki) of approximately 66 nmol/L Based on these pharmacological properties atazanavir holds research potential in anti-retroviral assays and studies involving HIV drug resistance and protease inhibition profiling
Medchemexpress LLC Acarbose | 56180-94-0 | 99.97% | C25H43NO18 | 1 G
Acarbose (BAY g 5421) is an orally active alpha-glucosidase inhibitor, acting as an antihyperglycemic agent with an IC50 of 11 nM. It can potentiate the hypoglycemic effects of sulfonylureas or insulin. It is suitable for various research applications.
- Orally active alpha-glucosidase inhibitor
- Potentiates hypoglycemic effects of sulfonylureas or insulin
- Decreases fasting blood glucose
- Regulates glucose tolerance
- Suppresses serum IL6 and TNF-α
- Decreases neointimal Ras and β-galactosidase expression
Medchemexpress LLC Sofosbuvir impurity 1 | C₁₈H₁₇F₅NO₅P | 5 MG
Sofosbuvir impurity 1 is an impurity of Sofosbuvir, primarily intended for scientific research or drug declaration purposes. This product is not for personal use.
- Molecular weight: 453.30
- Appearance: Solid
- Color: White to off-white
- Shipping conditions: Room temperature in continental US (may vary elsewhere)
- Storage: Three years at room temperature; two years at -80°C in solvent, one year at -20°C in solvent
Selleck Chemical LLC Enalaprilat Dihydrate 50mg 84680-54-6 MK-422 Dihydrate
Enalaprilat (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Osimertinib dimesylate | 2070014-82-1 | 99.2% | C30H41N7O8S2 | 50 MG
Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor with IC50s of 12 nM against EGFRL858R and 1 nM against EGFRL858R/T790M. It is effective in inhibiting EGFR phosphorylation in both sensitizing and T790M resistant EGFR mutant cell lines, demonstrating potent activity at low nanomolar concentrations. The compound also exhibits improved pharmacokinetic properties in rats, reduced hERG affinity, and improved IGF1R margins, showing excellent efficacy in preclinical tumor models.
- Irreversible and mutant selective EGFR inhibitor
- Potently inhibits EGFR phosphorylation in T790M mutant cell lines
- Effective against sensitizing EGFR mutant cells
- Shows improved pharmacokinetic properties and safety margins
- Demonstrates efficacy in tumor-bearing mice
- Soluble in water and DMSO for various applications
Sigma Aldrich Fine Chemicals Biosciences Aspartame European Pharmacopoeia (EP) Reference Standard | 22839-47-0 | MFCD00002724 |
Aspartame European Pharmacopoeia (EP) Reference Standard | Mol Wt: 294.3 | 22839-47-0 | MFCD00002724 |
Medchemexpress LLC Ketoconazole | 65277-42-1 | 99.6% | C26H28Cl2N4O4 | 1 G
Ketoconazole is an imidazole anti-fungal agent and a CYP3A4 and CYP24A1 inhibitor. It has been shown to produce features of androgen deficiency and is a potent exosome biogenesis and/or secretion inhibitor. This product is for research use only.
- Functions as an imidazole anti-fungal agent
- Acts as a CYP3A4 and CYP24A1 inhibitor
- Inhibits hepatic CYP450 and CYT b5 activities
- Enhances antiproliferative effects
- Increases systemic calcitriol exposure
- Promotes activation of caspase-independent apoptosis
- Potent exosome biogenesis and/or secretion inhibitor
Medchemexpress LLC (+)-Ketoconazole | 142128-59-4 | 99.8% | C26H28Cl2N4O4 | 50 MG
(+)-Ketoconazole is an imidazole anti-fungal agent and a CYP3A4 inhibitor. It also acts as a cytochrome P450 inhibitor. Clinically, it is indicated for candida infection, dermatophytosis, and folliculitis, but carries toxicity risks. This product is intended for research use only.
- Imidazole anti-fungal agent
- CYP3A4 and cytochrome P450 inhibitor
- Clinically indicated for candida infection, dermatophytosis, and folliculitis
- Associated with androgen deficiency, liver injuries, teratogenesis, and adrenal gland problems
- Solid, white to off-white appearance
- For research use only
Selleck Chemical LLC Regorafenib (BAY 73-4506) 10mM/1mL 755037-03-7 Fluoro-Sorafenib, Resihance, Stivarga
Regorafenib (BAY 73-4506, Fluoro-Sorafenib, Resihance, Stivarga) is a multi-target inhibitor for¿VEGFR1,¿VEGFR2,¿VEGFR3,¿PDGFR?,¿Kit (c-Kit),¿RET (c-RET)¿and¿Raf-1¿with¿IC50¿of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. Regorafenib induces¿autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Camptothecin 100mg 7689-03-4 NSC-100880, CPT
Camptothecin (NSC-100880, CPT) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 ?M in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Ifosfamide 50mg 3778-73-2 NSC109724, Isophosphamide
Ifosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Alkali Scientific Amoxicillin Trihydrate, 10 G
Amoxicillin Trihydrate is a broad spectrum penicillin class antibiotic widely used in microbiological and biochemical research. It works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. This compound is effective against a range of Gram positive and certain Gram negative bacteria and is frequently used in laboratory studies involving antimicrobial activity and bacterial growth control. In cell culture applications, it may be used to reduce bacterial contamination. Amoxicillin is also used in research focused on antibiotic resistance, pharmacological testing, and microbial inhibition, providing consistent and well characterized antibacterial performance.